Monday, February 23, 2015

Value of CACS Compared With ETT and Myocardial Perfusion Imaging for Predicting Long-Term Cardiac Outcome in Asymptomatic and Symptomatic Patients at Low Risk for Coronary Disease: Clinical Implications in a Multimodality Imaging World.

Over a 10-year follow-up, multivariate predictors of cardiac events were an abnormal SPECT (hazard ratio [HR]: 1.83), ischemia on treadmill stress testing (HR 1.70), decreasing exercise capacity (HR 1.11), and coronary artery calcium severity (HR 1.29).  (JACC Cardiovasc Imaging. 2015 Feb;8(2):134-44.)
Read More

Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with nonischaemic dilated cardiomyopathy using gated myocardial perfusion SPECT.

Phase standard deviation and phase histogram bandwith as determined by gated SPECT imaging is useful for the prediction of response to cardiac resynchronization therapy.  (Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with nonischaemic dilated cardiomyopathy using gated myocardial perfusion SPECT.)
Read More

The prognostic value of regadenoson myocardial perfusion imaging.

Compared to patients with normal perfusion (<5% stress perfusion defect), the hazard ratio for an adverse cardiac event during a 4-yr follow-up period was 2.7 for patients with 5% to 10% perfusion defect; 3.3 for patients with 10% to 20% perfusion defect, and 4.1 for patients with a greater than 20% perfusion defect on regadenoson SPECT nuclear imaging.  (J Nucl Cardiol. 2015 Feb 14.a)
Read More

Sunday, February 8, 2015

(11)C-Pittsburgh B PET Imaging in Cardiac Amyloidosis.

The PiB compound has been promising for detection of amyloid deposits in the brain. In this study of 22 patients,(11)C-PiB PET/CT was positive in 13 of the 15 with biopsy-proven cardiac amyloidosis, and negative in 0 out of the 7 patients without cardiac amyloidosis.  (JACC Cardiovasc Imaging. 2015 Jan;8(1):50-9.)
Read More

Thursday, December 4, 2014

Do Vertebral Fractures Predict Cardiovascular Events?

QUESTION: can the presence of vertebral fractures on chest CT help predict cardiovascular events?

METHODS: case-cohort design looking at 5,679 patients undergoing chest CT. Follow-up was for a median duration of 4.4 years. Cases were defined as patients who subsequently developed a cardiovascular event (n = 493).

RESULTS: Cases were more likely to be older males. Prevalent vertebral fractures increased the risk of a cardiovascular event by about 30%.

CONCLUSION: Prevalent vertebral fractures on routine clinical chest CT are related to future cardiovascular events but do not have additional prognostic value to models that already include age, gender and cardiovascular calcifications.

COMMENT: routine chest CT scans do not provide a coronary artery calcium score. This study may help risk stratify patients when the CAC isn't available.

Int J Cardiovasc Imaging. 2014 Dec 2;