OBJECTIVE: This study looked at the relationship between sympathetic innervation and metabolism of the non-infarcted myocardium in patients with prior myocardial infarction.
PARTICIPANTS: 19 patients with previous myocardial infarction
METHODS: cardiac sympathetic innervation was assessed by 11C-hydroxyephedrine (HED) retention by positron emission tomography (PET).
- 11C-HED retention was positively correlated with left ventricular ejection fraction
- In patients with a left ventricular end systolic volume of over 41 mL, there was a reduced 11C-HED retention.
- After myocardial infarction, there is impaired sympathetic innervation of the infarcted and non-infarcted myocardium.